Erythropoietin

GWB-974545

Epo1Host Animal: Mouse

Erythropoietin

PBS. pH 7. 4Applications Notes : Suitable for use in ELISA and Western blot. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded. Recommended pair for sandwich immunoassay: Capture: 20-511-240534; Detection: 20-511-240536.

Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.

Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals. Pharmaceutical: Used for the treatment of anemia. Available under the names Epogen (Amgen) Epogin (Chugai) Epomax (Elanex) Eprex (Janssen-Cilag) NeoRecormon or Recormon (Roche) Dynepo (Shire Pharmaceuticals) and Procrit (Ortho Biotech). Variations in the glycosylation pattern of EPO distinguishes these products. Epogen Epogin Eprex and Procrit are generically known as epoetin alfa NeoRecormon and Recormon as epoetin beta Dynepo as epoetin delta and Epomax as epoetin omega. Epoetin zeta is the name used for some \' biosimilars\' forms of epoetin alfa and is available under the names Silapo (Stada) and Retacrit (Hospira). Darbepoetin alfa is a form created by 5 substitutions (Asn-57 Thr-59 Val-114 Asn-115 and Thr-117) that create 2 new N-glycosylation sites. It has a longer circulating half-life in vivo. It is available under the name Aranesp (Amgen). EPO is being much misused as a performance-enhancing drug in endurance athletes.