glyceraldehyde-3-PDH

ArtNr	20-511-240776
Hersteller	GENWAY
Menge	1 mg
Kategorie	Oncology Antibodies Western Blot ELISA Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Applikationen	WB, ELISA
Clon	4G5
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-A90098
Similar products	20-511-240776
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Genway ID:	GWB-A90098
Isotype:	IgG1
Clone:	4G5Host Animal: Mouse. Hybridization of Sp2/0 myeloma cells with spleen cells from Balb/c mice.
Immunogen:	Rabbit muscle GAPDH
Specificity:	Recognizes GAPDH monomer (36 kDa) and the dimmer form. Does not react with the tetrameric form. Reacts with GAPDH from human. bovine. pig. goat. dog. rabbit. cat. rat. mouse and fish.
Type of Product:	Monoclonal Antibodies to Enzymes
Concentration:	2. 2mg/ml (Sigma protein assay kit)Preservatives: NaN3
Buffer:	PBS. pH 7. 4Applications Notes : Suitable for use in ELISA. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded. Recommended pairs for sandwich immunoassay:. Capture Detection. 20-511-240778 20-511-240776. 20-511-240785 20-511-240776
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. MAb to glyceraldehyde-3-PDH. Monoclonal Antibody to Rabbit Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
Function:	Independent of its glycolytic activity it is also involved in membrane trafficking in the early secretory pathway.
Catalytic Activity:	D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH.
Pathway:	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.
Subunit:	Homotetramer. Binds PRKCI.
Subcellular Location:	Cytoplasm. Cytoplasm perinuclear region. Membrane. Note=Postnuclear and Perinuclear regions.
Ptm:	Reversible S-nitrosylation of Cys-152 inhibits enzymatic activity and increases endogenous ADP-ribosylation which inhibits the enzyme in a non-reversible manner. The latter modification is more likely to be a pathophysiological event associated with inhibition of gluconeogenesis (By similarity).
Similarity:	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

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Menge: 1 mg

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