MOUSE ANTI MHC CLASS II H-2I-Ak/s:Biotin

GWB-BB5C9D

IgG1Species Cross Reactivity: Reacts with: MouseN. B. Antibody reactivity and working conditions may vary between species.

The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In mice this complex is referred to as the H-2 region. In rats this complex is referred to as the RT1 region.

Also cross reacts with a polymorphic determinant on mouse strains of the H-2 haplotypes k and s. Analysis of recombinant mouse strains has mapped the OX-6 determinant to the H-2I-A region. (1) (6) This product is routinely tested in flow cytometry on rat splenocytes. Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROL:BiotinRecommended Secondary Antibodies: STREPTAVIDIN [1] \" Nucleotide sequence of the human ECSIT cDNA. \" S. N. Brady K. J. Moynagh P. N. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) VARIANT CYS-278. [2] \" Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201). \" Ebert L. Schick M. Neubert P. Schatten R. Henze S. Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). [3] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Eye Lung and Pancreas. [4] \" Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly. \" Vogel R. O. Janssen R. J. R. J. van den Brand M. A. M. Dieteren C. E. J. Verkaart S. Koopman W. J. H. Willems P. H. G. M. Pluk W. van den Heuvel L. P. W. J. Smeitink J. A. M. Nijtmans L. G. J. Genes Dev. 21:615-624(2007) [PubMed: 17344420] [Abstract]Cited for: SUBCELLULAR LOCATION MASS SPECTROMETRY INTERACTION WITH NDUFAF1. [5] Colinge J. Superti-Furga G. Bennett K. L. Submitted (OCT-2008) to UniProtKBCited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].