CD103

GWB-CF9E4D

3682

LF61

Spleen cells from immunised BALB/c mice were fused with cells of the mouse NSO myeloma cell line.

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Use 10ul of the suggested working dilution to label 106 cells in 100ul. Summary: ITGAE encodes integrin alpha chain E. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin undergoes post-translational cleavage in the extracellular domain that yields disulfide-linked heavy and light chains In combination with beta 7 (ITGB7) these chains form the E-cadherin binding integrin known as \' human mucosal lymphocyte-1\' antigen (HML-1). This integrin is preferentially expressed on human intestinal intraepithelial lymphocytes (IEL) and in addition to adhesion it may serve as an accessory molecule for IEL activation. Summary: ITGAE encodes integrin alpha chain E. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin undergoes post-translational cleavage in the extracellular domain that yields disulfide-linked heavy and light chains In combination with beta 7 (ITGB7) these chains form the E-cadherin binding integrin known as \' human mucosal lymphocyte-1\' antigen (HML-1). This integrin is preferentially expressed on human intestinal intraepithelial lymphocytes (IEL) and in addition to adhesion it may serve as an accessory molecule for IEL activation. 1. Flenghi. L. et al. (1990) LF61: a new monoclonal antibody directed against a trimeric molecule (150kD. 125kD. 105kD) associated with hairy cell leukaemia. Br. J. Haem. 76: 451-459. 2. Falini. B. et al. (1990) Selection of a panel of monoclonal antibodies for monitoring residual disease in peripheral blood and bone marrow of interferon-treated hairy cell leukaemia patients.