CD161

GWB-66F13C

CD161

Purified splenic NK cells from the LEW rat strain.

This product recognises the rat CD161 protein (also known as NKR-PI) a 60kD glycoprotein expressed on rat NK cells and T cell subpopulations. This antibody competes with clone 3. 2. 3 for binding to antigen.

Phosphate buffered saline pH7. 4

Suggested

Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1 3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.

Membrane; Single-pass type II membrane protein (Potential).

By IL12 in NK cells.

Contains 1 C-type lectin domain. 1. Sedgwick. J. D. et al. (1998) Central Nervous system microglial cell activation and proliferation follows direct interation with Tissue-infiltrating T Cell Blasts. 2. Tliba. O. et al. (2002) Evaluation of the hepatic NK cell response during the early phase of Fasciola hepatica infection in rats.