PCNA


ArtNr	20-783-70672
Hersteller	GENWAY
Menge	6 ml
Kategorie	Oncology Antibodies Immunohistochemistry Primary Antibodies By Organ Bladder Cancer
Typ	Antibody
Applikationen	IHC
Clon	PC10Suggeste
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-8A87E1
Similar products	20-783-70672
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Genway ID:	GWB-8A87E1
Specificity:	PCNANCBI
Gene ID:	5111
Isotype:	IgG2a
Clone:	PC10Suggested
Dilution:	Immunohistology - Pariffin Neat
Immunogen:	Rat PCNA made in the protein A expression vector pR1T2T
Specificity Note:	This product recognises the proliferating cell nuclear antigen (PCNA) a nuclear protein vital for cellular DNA synthesis. This clone has been reported to be suitable for Western blotting. is recommended for this application. This clone has been reported to be suitable for immunoprecipitation. is recommended for this application.
Immunohistology:	This product does not require protein digestion pre-treatment of paraffin sections. This product requires antigen retrieval using heat pre-treatment prior to staining of paraffin sections. Histology: Tonsil or colon
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum Albumin Summary: The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. Summary: The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq]. 1. Matthews. M. B. et al. (1984) Identity of the proliferating cell nuclear antigen and cyclin. 2. Ogata. K. et al. (1985) Purification and N-terminal amino acid sequence of proliferating cell nuclear antigen (PCNA)/cyclin and development of ELISA for anti-PCNA antibodies. 3. Garcia. R. L. et al. (1989) Analysis of proliferation grade using anti-PCNA/cyclin monoclonal antibodies in fixed. embedded tissues compared with flow cytometry. 4. Landberg. G. et al. (1990) Flow cytometric multiparameter analysis of proliferating cell nuclear antigen/cyclin and ki-67
Antigen:	a new view of the cell cycle. 5. Wilson. G. D. et al. (1992) Flow cytometric characterisation of proliferating cell nuclear antigen using the monoclonal antibody PC10. 6. Elsasser. H. P. et al. (1994) Growth of rat pancreatic acinar cells quantitated with a monoclonal antibody against the proliferating cell nuclear antigen. 7. Prosperi. E. et al. (1993) Proliferating cell nuclear antigen complex formation induced by ultra violet irradiation in human quiescent fibroblasts as detected by immunostaining and flow cytometry.

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