CD147

GWB-40692C

12215

OX114

This product recognises mouse CD147 (also known as basigin). CD147 is a cell surface glycoprotein that is widely expressed on leukocytes red cells platelets and endothelial cells. The reported functions of CD147 are diverse and include involvement in T-cell activation cell adhesion and induction of matrix metalloproteinases. OX-114 recognises both isoforms of CD147 the common form containing 2 Ig-like domains and the rare form containing 3 Ig-like domains. This antibody is routinely tested in flow cytometry on mouse splenocytes. Note that for staining of whole blood samples increased amounts of antibody may be required due to the presence of CD147 on erythrocytes.

Phosphate buffered saline pH7. 4

Use 10ul of the suggested working dilution to label 106 cells in 100ul Suggested

Plays pivotal roles in spermatogenesis embryo implantation neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1 SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro promotes outgrowth of astrocytic processes (By similarity).

Cell membrane; Single-pass type I membrane protein (By similarity). Melanosome. Note=Colocalizes with SLC16A1 and SLC16A8 (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.