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MYELIN PROTEOLIPID PROTEIN

MYELIN PROTEOLIPID PROTEIN


ArtNr	20-783-72615
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Neuroscience Neural Lineage Markers Antibodies Immunohistochemistry Western Blot Primary Antibodies By Organ Heart & Blood Cancer Neuronal Cell Markers
Typ	Antibody
Applikationen	WB, IHC
Clon	plpc1
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-2BBCF0
Similar products	20-783-72615
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Genway ID:	GWB-2BBCF0
Specificity:	MYELIN PROTEOLIPID PROTEIN
Specificity:	MYELIN PROTEOLIPID PROTEIN
Clone:	plpc1
Immunogen:	Synthetic peptide CGRGTKF corresponding to C terminal region of myelin proteolipid protein.
Fusion Partner:	Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line.
Specificity Note:	This product recognises myelin proteolipid protein (PLP) in many mammalian species. This antibody also recognises DM20. PLP encodes the major protein components of compact CNS myelin and mutations in the PLP gene can lead to severe dysmyelinating disease.
Preparation:	Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Preservative Stabilisers:		0. 09%Sodium Azide
Function:	This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
Subcellular Location:	Membrane; Multi-pass membrane protein.
Disease:	Defects in PLP1 are the cause of Pelizaeus-Merzbacher disease (PMD) [MIM:312080]. PMD is an X-linked recessive dysmyelinating disorder of the central nervous system in which myelin is not formed properly. PMD is characterized clinically by nystagmus spastic quadriplegia ataxia and developmental delay.
Disease:	Defects in PLP1 are the cause of spastic paraplegia X-linked type 2 (SPG2) [MIM:312920]. SPG2 is characterized by spastic gait and hyperreflexia. In some patients complicating features include nystagmus dysarthria sensory disturbance mental retardation optic atrophy.
Similarity:	Belongs to the myelin proteolipid protein family.

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Menge: 0.1 mg

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