CD122


ArtNr	20-783-74182
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies Flow Cytometry Immunoprecipitation Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Applikationen	FC, IP
Clon	TM-BETA 1
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-AF0B64
Similar products	20-783-74182
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Genway ID:	GWB-AF0B64
Specificity:	CD122NCBI
Gene ID:	16185
Specificity:	CD122
Clone:	TM-BETA 1
Immunogen:	Cells from murine IL-2RB+ transformant TART-mBeta.
Fusion Partner:	Lymph node (cells from immunised Sprague Dawley rats were fused with cells of the mouse PA1 myeloma cell line.
Specificity Note:	This product recognises the murine CD122 cell surface glycoprotein a 75-85kD molecule also known as interleukin-2 receptor (IL-2R) beta chain. In mouse CD122 is primarily expressed on natural killer (NK) cells and at lower levels on lymphocyte subsets monocytes and macrophages. CD122 can associate with the IL-2R alpha chain (CD25) and CD132 to form a functional high affinity receptor complex that binds IL-2. CD132/CD122 heterodimers can also be formed which bind IL-2 with intermediate affinity. IL-2 binding to the IL-2R is important in the generation and differentiation of T lymphocytes and NK cells. Clone TM-beta 1 is reported to block IL-2 high affinity binding to the IL-2R beta receptor (1). We recommend the use of for this purpose.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - 1/50 - 1/100
Function:	Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.
Subunit:	Non-covalent dimer of an alpha and a beta chains. IL2R exists in 3 different forms: a high affinity dimer an intermediate affinity monomer (beta chain) and a low affinity monomer (alpha chain). The high and intermediate affinity forms also associate with a gamma chain. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Domain:	The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
Domain:	The box 1 motif is required for JAK interaction and/or activation.
Similarity:	Belongs to the type I cytokine receptor family. Type 4 subfamily.
Similarity:	Contains 1 fibronectin type-III domain. 1. Tanaka. T. et. al. (1991) A novel monoclonal antibody against murine IL-2 receptor beta-chain.

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Menge: 0.1 mg

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