DECTIN-2

GWB-39C5D8

56620

D2. 11E4

This product recognises mouse DC-associated C-type lectin-2 (Dectin-2) a type II transmembrane protein that is a member of the C-type lectin superfamily. In mouse dectin-2 is predominantly expressed on tissue macrophages and some dendritic cells. Clone D2. 11E4 does not stain brain microglia or meningeal macrophages. Significant expression of Dectin-2 has been reported on macrophages in the red pulp and marginal zones of the spleen kupffer cells in the liver and alveolar macrophages in the lung. Peripheral blood monocytes express low levels of dectin-2 but transient up-regulation of expression has been demonstrated on monocytes at sites of inflammation. The function of dectin-2 has not been fully determined but studies suggest a possible role in immune-surveillance.

Phosphate buffered saline pH7. 4

Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested

Contains 1 C-type lectin domain. 1. Taylor. P. R. et al. (2005) Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivo.