Pax-5

Rabbit IgG

Tonsil Cellular

Synthetic peptides from C-terminus of human Pax-5 protein. Pax-5 is a B cell specificactivator protein (BSAP). In the early stages of B cell developmemt Pax-5 influences the expression of several B-cell-specific genes such as CD19 and CD20. Pax-5 is expressed primarily inpro- pre- and mature B cells but not inplasma cells. Interestingly Pax-5 mRNA is transiently detected in the mesencephalon and spinal cord during embryogenesis. Expression then shifts to the fetal liver and correlates with the onset of B lymphopoiesis. This indicates that Pax-5 is important in B cell development but may also have a role in proper neuronal development.