BRCA1

GWB-953A90

MCF-7 cells Cellular

A synthetic peptide corresponding to C-terminal of human BRCA1 protein. BRCA1 (breast and ovarian cancer susceptibility protein 1) is a RING finger protein containing a BRCT domain. BRCA1 exists as a heterodimer with 22 possible isoforms. BRCA1 localizes to the mitotic spindle microtubules centriole walls pericentriolar fibers at centrosomes. Unphosphorylated BRCA1 localizes on chromosomes from metaphase through telophase; phosphorylated BRCA1 acts as a tumor suppressor and can function as a secreted growth inhibitory protein participate in transcription coupled repair of oxidative DNA damage X-chromosome inactivation and can function as a E3 ubiquitin ligase. BRCA1 can be modified by glycosylation ubiquitination and phosphorylation by CDK4 ATM/ATR cdk2 and hChk2. The BRCA1 protein has been reported to interact with RNA polymerase II holoenzyme and BARD1. Inherited loss of BRCA1 function confers an increased susceptibility for both breast and ovarian cancer.