CDC37

Rabbit IgG

Recombinant protein encoding aa 108-378 of human CDC37. The mammalian p50Cdc37 was identified as a protein kinase-targeting subunit of the molecular chaperone Hsp90. Several protein kinases (e. g. pp60(src) v-Raf) exist in heterocomplexes with hsp90 and a 50kDa protein that is the mammalian homolog of the yeast cell cycle control protein Cdc37. In mouse fibroblasts a primary target of Cdc37 is Cdk4. This kinase is activated by D-type cyclins and functions in passage through G1. Cdc37 is coexpressed with cyclin Dl in cells undergoing programmed proliferation in vivo consistent with a positive role in cell cycle progression. The p50Cdc37 plays a general role in signaling pathways dependent on intrinsically unstable protein kinases and reveals a previously unrecognized chaperone-dependent step in the production of Cdk4/cyclin D complexes.