TS

GWB-66FF18

Colon cancer

A synthetic peptide corresponding to human TS Thymidylate Synthase (TS) (EC 2. 1. 1. 45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5 10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal gastric head and neck and breast carcinomas.