STAT6

GWB-35F4B6

Jurkat cells. Tonsil and placenta

A synthetic peptide derived from C-terminal of human STAT6 Stat6 protein is a transcription factor activated by cytokines particularly interleukin-4 and IL13. (Stat6-/-) were found to be deficient in IL-4-mediated functions including Th2 helper T-cell differentiation expression of cell surface markers T-cell proliferation immunoglobulin class switching to IgE and partial loss of IL-4 mediated proliferation. Stat6 mRNA has been detected in peripheral blood lymphocytes colon intestine ovary prostate thymus spleen kidney liver lung and placenta. Stat6 is critically involved in Th2 immune response.