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IkappaB-alpha (Phospho-Ser32/Ser36) Antibody Blocking Peptide

IkappaB-alpha (Phospho-Ser32/Ser36) Antibody Blocking Peptide

ArtNr	06-785-213132
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Peptides & Proteins Peptides
Typ	Peptides
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-108697
Similar products	06-785-213132
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Genway ID:	GWB-108697
Function:	Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses becomes phosphorylated promoting ubiquitination and degradation enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.
Subunit:	Interacts with RELA; the interaction requires the nuclear import signal. Interacts with NKIRAS1 and NKIRAS2. Part of a 70-90 kDa complex at least consisting of CHUK IKBKB NFKBIA RELA IKBKAP and MAP3K14. Interacts with HBV protein X. Interacts with RWDD3; the interaction enhances sumoylation.
Subcellular Location:	Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export (By similarity).
Induction:	Induced in adherent monocytes.
Ptm:	Phosphorylated; disables inhibition of NF-kappa-B DNA-binding activity.
Ptm:	Ubiquitinated; subsequent to stimulus-dependent phosphorylation on serines.
Ptm:	Sumoylated; sumoylation requires the presence of the nuclear import signal.
Disease:	Defects in NFKBIA are a cause of autosomal dominant anhidrotic ectodermal dysplasia with immunodeficiency (AD-EDA-ID) [MIM:164008]. Ectodermal dysplasias (EDs) constitute a heterogeneous group of developmental disorders affecting tissues of ectodermal origin. EDs are characterized by abnormal development of two or more ectodermal structures such as hair teeth nails and sweat glands with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia.
Similarity:	Belongs to the NF-kappa-B inhibitor family.
Similarity:	Contains 5 ANK repeats.

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Menge: 0.1 mg

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Lieferung vsl. bis 28.08.2025

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