CIRBP Antibody (C-term)

Synthetic Peptide

CIRBP is cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. It acts as a translational activator and seems to play an essential role in cold-induced suppression of cell proliferation. It binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. This protein acts as a translational repressor (By similarity) and promotes assembly of stress granules (SGs), when overexpressed.

Polyclonal

1153

Affinity Purified Rabbit Polyclonal Antibody (Pab)

Western blot analysis of CIRBP Antibody (C-term) (Cat. #AP9139b) in Y79 cell line lysates (35ug/lane). CIRBP (arrow) was detected using the purified Pab.

1:1000

WB

CIRBP Antibody (C-term) (Cat. #AP9139b) IHC analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CIRBP Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

1:50~100

Ha, M, Rat

18648

HUMAN

NP_001271.1