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Anti-Rhesus IgG2 (Clone 3C10.1) - Purified No Carrier Protein - 100 µg

ArtNr LEIN-R1504-100ug
Hersteller Leinco Technologies
Menge 100 ug
Quantity options 100 ug 500 ug
Kategorie
Typ Antibody Monoclonal
Applikationen IF, ELISA, FA
Clon 3C10.1
Specific against other
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Versandbedingung Gekühlt
Lieferbar
Manufacturer - Category
Monoclonal Antibodies|Non-Human Primate Immunoglobulins|Primary Monoclonal Antibodies
Manufacturer - Targets
Rhesus IgG
Shipping Temperature
2 - 8°C Wet Ice
Storage Conditions
Antibodies may be stored sterile as received at 2-8°C for up to one year. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≥ -80°C. Avoid Repeated Freeze Thaw Cycles.
Product Description
As part of preclinical vaccine development, particularly for HIV, Indian rhesus macaques (Macaca mulatta) are used to evaluate antibody-based correlates of vaccine-mediated protection1. Four IgG subclasses are present in rhesus, but subclass numbering between rhesus and humans is not strictly consistent between species. Based on sequence alignment of the CH2 region responsible for FcγR recognition, rhesus subclasses are most similar to human IgG1. Most substitutions between rhesus and humans are located distal to the FcγR contact residues, except for H38 which borders an FcγR contact residue and is substituted to Q in all rhesus subclasses. Additionally, rhesus IgG2 has a deletion of P2, a residue proximal to the FcγR contact residues. Rhesus IgG2 binds to FcγR-conjugated fluorescently coded microspheres in a glycosylation dependent manner. Rhesus IgG2 and IgG3 can be specifically detected using antibodies raised against their hinges. In serum, rhesus IgG2 is the second most abundant Ig subclass, after IgG1.3C10.1 was generated by immunizing mice with overlapping peptides derived from the IgG hinge region, VVHEPSNTKVDKTVGLPCRSTCPPCP and DKTVGLPCRSTCPPCPAELLGCPSVF1. Administration of antibody to rhesus macaques results in a moderate reduction of CD8+ T cells in blood.
Manufacturer - Research Area
Immunoglobulins
Concentration
≥1.0 mg/ml
Formulation
This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Antigen Distribution
IgG2 is found in serum.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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