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4-IBP Europäischer Partner

ArtNr HY-100155-50mg
Hersteller MedChem Express
CAS-Nr. 155798-08-6
Menge 50 mg
Quantity options 100 mg 10 mM/1 mL 10 mg 50 mg 5 mg
Kategorie
Typ Inhibitors
Specific against other
Purity 98.90
Citations [1]Mégalizzi V, et al. 4-IBP, a sigma1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells, in vitro and sensitizes them in vitro and in vivo to cytotoxic insults of proapoptotic and proautophagic drugs. Neoplasia. 2007 May;9(5):358-69.|[2]Bermack JE, et al. Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands. Br J Pharmacol. 2001 Oct;134(3):691-9.|[3]Debeir O, et al. Videomicroscopic extraction of specific information on cell proliferation and migration in vitro. Exp Cell Res. 2008 Oct 1;314(16):2985-98.|[4]Amer MS, et al. Inhibition of endothelial cell Ca²⁺ entry and transient receptor potential channels by Sigma-1 receptor ligands. Br J Pharmacol. 2013 Mar;168(6):1445-55.|[5]Mégalizzi V, et al. 4-IBP, a sigma1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells, in vitro and sensitizes them in vitro and in vivo to cytotoxic insults of proapoptotic and proautophagic drugs. Neoplasia. 2007 May;9(5):358-69. |[6]Liu X, et al. Influence of Trishomocubanes on Sigma Receptor Binding of N-(1-Benzylpiperidin-4-yl)-4-[123I] iodobenzamide In Vivo in the Rat Brain. Medicinal Chemistry, 2005, 1(1): 31-38.
Smiles O=C(NC1CCN(CC2=CC=CC=C2)CC1)C3=CC=C(I)C=C3
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias 155798-08-6
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Type
Reference compound
Manufacturer - Applications
Cancer-programmed cell death
Manufacturer - Targets
Apoptosis; Autophagy; Sigma Receptor
Shipping Temperature
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight
420.29
Product Description
4-IBP is a selective σ₁ receptor agonist with high affinity for the σ₁ receptor (Ki =1.7 nM) and moderate affinity for the σ₂ receptor (Ki = 25.2 nM). 4-IBP can make cancer cells more sensitive to the cytotoxic effects of pro-apoptotic and pro-autophagic compounds. 4-IBP significantly reduces the migration ability of a variety of cancer cells. 4-IBP is mainly used in glioblastoma, non-small cell lung cancer and prostate cancer research[1][2][3][4][5][6].
Manufacturer - Research Area
Cancer
Solubility
DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway
Apoptosis; Autophagy; Neuronal Signaling
Isoform
Sigma 1 Receptor; Sigma 2 Receptor
Clinical information
No Development Reported

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 50 mg
Lieferbar: In stock
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