4-IBP

Item no.	HY-100155-50mg
Manufacturer	MedChem Express
CASRN	155798-08-6
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Brain Cancer
Type	Inhibitors
Specific against	other
Purity	98.90
Citations	[1]Mégalizzi V, et al. 4-IBP, a sigma1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells, in vitro and sensitizes them in vitro and in vivo to cytotoxic insults of proapoptotic and proautophagic drugs. Neoplasia. 2007 May;9(5):358-69.\|[2]Bermack JE, et al. Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands. Br J Pharmacol. 2001 Oct;134(3):691-9.\|[3]Debeir O, et al. Videomicroscopic extraction of specific information on cell proliferation and migration in vitro. Exp Cell Res. 2008 Oct 1;314(16):2985-98.\|[4]Amer MS, et al. Inhibition of endothelial cell Ca²⁺ entry and transient receptor potential channels by Sigma-1 receptor ligands. Br J Pharmacol. 2013 Mar;168(6):1445-55.\|[5]Mégalizzi V, et al. 4-IBP, a sigma1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells, in vitro and sensitizes them in vitro and in vivo to cytotoxic insults of proapoptotic and proautophagic drugs. Neoplasia. 2007 May;9(5):358-69. \|[6]Liu X, et al. Influence of Trishomocubanes on Sigma Receptor Binding of N-(1-Benzylpiperidin-4-yl)-4-[123I] iodobenzamide In Vivo in the Rat Brain. Medicinal Chemistry, 2005, 1(1): 31-38.
Smiles	O=C(NC1CCN(CC2=CC=CC=C2)CC1)C3=CC=C(I)C=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	155798-08-6
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis; Autophagy; Sigma Receptor
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	420.29
Product Description	4-IBP is a selective σ₁ receptor agonist with high affinity for the σ₁ receptor (Ki =1.7 nM) and moderate affinity for the σ₂ receptor (Ki = 25.2 nM). 4-IBP can make cancer cells more sensitive to the cytotoxic effects of pro-apoptotic and pro-autophagic compounds. 4-IBP significantly reduces the migration ability of a variety of cancer cells. 4-IBP is mainly used in glioblastoma, non-small cell lung cancer and prostate cancer research[1][2][3][4][5][6].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Autophagy; Neuronal Signaling
Isoform	Sigma 1 Receptor; Sigma 2 Receptor
Clinical information	No Development Reported

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HY-100155-50mg-safety-datasheet.pdf