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OTS964 (hydrochloride)

OTS964 (hydrochloride)

ArtNr	HY-12467-25mg
Hersteller	MedChem Express
CAS-Nr.	1338545-07-5
Menge	25 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 2mg 50 mg 5 mg
Kategorie	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Typ	Inhibitors
Specific against	other
Purity	99.74
Formula	C23H25ClN2O2S
Citations	Cell Death Dis. 2019 Aug 5;10(8):583. <br/>Cell. 2021 Jun 10;184(12):3143-3162.e32.<br/>Nature. 2022 Sep;609(7928):829-834.<br/>SSRN. 2022 Nov 21.<br/>Adv Sci (Weinh). 2024 Feb 2:e2308496.<br/>iScience. 2023 Jun 16.<br/>J Eur Acad Dermatol Venereol. 2023 Dec 22.<br/>[1]Matsuo Y, et al. TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition ofcytokinesis. Sci Transl Med. 2014 Oct 22;6(259):259ra145.<br/>[2]Lin A, et al. Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials. Sci Transl Med. 2019 Sep 11;11(509).<br/>[3]Lu H, et al. TOPK inhibits autophagy by phosphorylating ULK1 and promotes glioma resistance to TMZ. Cell Death Dis. 2019 Aug 5;10(8):583.
Smiles	OC1=CC(C)=C2C(C3=C(SC=C3)C(N2)=O)=C1C4=CC=C([C@@H](C)CN(C)C)C=C4.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1338545-07-5
Lieferbar
Product Description	OTS964 hydrochloride is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor with an IC50 of 28 nM[1]. OTS964 hydrochloride is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a Kd of 40 nM[2].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	428.97
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 83.33 mg/mL\|H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Apoptosis; CDK; TOPK
Manufacturers Target	Apoptosis; CDK; TOPK
Isoform	CDK11
Manufacturers Pathway	Apoptosis; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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HY-12467-25mg-safety-datasheet.pdf