Atorvastatin (hemicalcium salt)

ArtNr	HY-17379-10mg
Hersteller	MedChem Express
CAS-Nr.	134523-03-8
Menge	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 200 mg 500 mg 50 mg 5 mg
Kategorie	Metabolism Cholesterol & Lipid Metabolism Cardiovascular Research Atherosclerosis Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.94
Citations	[1]Santodomingo-Garzón T, et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol. 2006 Sep;149(1):14-22.\|[2]Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61.\|[3]Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82.\|[4]Song XJ, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 2011;8(7):564-72.\|[5] Li Y, et al. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS One. 2017 Apr 3;12(4):e0174821. Adv Sci (Weinh). 2024 Jul 5:e2403451.\|Arch Biochem Biophys. 2025 Jan 21:765:110316.\|bioRxiv. 2024 Jul 3:2024.07.01.601474.\|Cell Death Dis. 2021 May 13;12(5):482.\|Endocrinology. 2018 May 1;159(5):2008-2021.\|Free Radic Biol Med. 2024 May 2:S0891-5849(24)00435-0.\|Front Bioeng Biotechnol. 2022 Mar 17;10:826093.\|Pharmaceutics. 2022, 14(1), 176.\|Acta Pharmacol Sin. 2024 Mar 8.\|Arterioscler Thromb Vasc Biol. 2022 May;42(5):644-658.\|Biomed Pharmacother. 2023 Aug 12;166:115323.\|Biotechnol Bioeng. 2021 Sep 3.\|Cancer Lett. 2022 Oct 19;215976.\|Cell Cycle. 2019 Dec;18(23):3337-3350.\|Cell Cycle. 2021 Sep 8;1-14.\|Emerg Microbes Infect. 2025 Feb 19:2470371.\|Endocrinology. 2022 May 18;bqac076.\|Eur J Pharmacol. 2023 Aug 1;956:175938.\|Eur J Pharmacol. 2023 Dec 21:176261.\|Eur J Pharmacol. 2025 Feb 5:177357.\|Exp Cell Res. 2023 Oct 23:113829.\|Front Cell Dev Biol. 2022 Mar 3;10:806081.\|Inflammation. 2024 Oct 31.\|Int J Mol Sci. 2023 Apr 19, 24(8), 7492.\|J Appl Toxicol. 2024 Apr 19\|J Appl Toxicol. 2024 Apr 19.\|J Mol Neurosci. 2021 Sep 26.\|J Nat Prod. 2022 Jun 24.\|J Neuroimmunol. 2020 Oct 24;350:577429.\|J Tradit Complement Med. 2024 Mar 29.\|Life Sci. 2025 Mar 17:123571.\|Med Gas Res. 2024 March 28.\|MedComm. 2024 Aug 31.\|Mol Cell. 2021 Jul 1;81(13):2736-2751.e8.\|Naunyn Schmiedebergs Arch Pharmacol. 2023 Jun 8.\|Oncogene. 2022 Oct 31.\|Orebro University. 2024.\|Phytomedicine. 2023 Jul 26;119:154997.\|Proteomics. 2023 May 4;e2300041.\|Research Square Preprint. 2021 Dec.\|Research Square Preprint. 2022 Jun.\|Research Square Preprint. 2024 Apr 9.\|Sci Rep. 2020 Jan 28;10(1):1308.\|Signal Transduct Target Ther. 2023 Dec 25;8(1):457.
Smiles	FC1=CC=C(C2=C(C3=CC=CC=C3)C(C(NC4=CC=CC=C4)=O)=C(C(C)C)N2CC[C@@H](O)C[C@@H](O)CC([O-])=O)C=C1.[0.5Ca2+]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CI-981,Atorvastatin hemicalcium
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Autophagy; Ferroptosis; HMG-CoA Reductase (HMGCR)
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	577.67
Product Description	Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3].
Manufacturer - Research Area	Metabolic Disease; Inflammation/Immunology; Cancer
Solubility	DMSO: ≥ 50 mg/mL\|H2O: < 0.1 mg/mL
Manufacturer - Pathway	Apoptosis; Autophagy; Metabolic Enzyme/Protease
Clinical information	Launched

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HY-17379-10mg-safety-datasheet.pdf