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Atorvastatin (hemicalcium salt)

Atorvastatin (hemicalcium salt)

ArtNr	HY-17379-200mg
Hersteller	MedChem Express
CAS-Nr.	134523-03-8
Menge	200 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 200 mg 500 mg 50 mg 5 mg
Kategorie	Metabolism Cholesterol & Lipid Metabolism Cardiovascular Research Atherosclerosis Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.94
Citations	[1]Santodomingo-Garzón T, et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol. 2006 Sep;149(1):14-22.\|[2]Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61.\|[3]Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82.\|[4]Song XJ, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 2011;8(7):564-72.\|[5] Li Y, et al. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS One. 2017 Apr 3;12(4):e0174821. Adv Sci (Weinh). 2024 Jul 5:e2403451. Arch Biochem Biophys. 2025 Jan 21:765:110316. bioRxiv. 2024 Jul 3:2024.07.01.601474. Cell Death Dis. 2021 May 13;12(5):482. Endocrinology. 2018 May 1;159(5):2008-2021. Free Radic Biol Med. 2024 Aug 1:220:179-191. Front Bioeng Biotechnol. 2022 Mar 17;10:826093. Nat Metab. 2025 Sep 22. Pharmaceutics. 2022 Jan 12;14(1):176. Acta Diabetol. 2025 Mar 27. Acta Pharmacol Sin. 2024 Jun;45(6):1316-1320. Arterioscler Thromb Vasc Biol. 2022 May;42(5):644-658. Biomed Pharmacother. 2023 Oct:166:115323. Biotechnol Bioeng. 2021 Dec;118(12):4687-4698. Cancer Lett. 2023 Jan 1:552:215976. Cell Cycle. 2019 Dec;18(23):3337-3350. Cell Cycle. 2021 Oct;20(20):2160-2173. Chem Biol Interact. 2025 Oct 22:420:111671. Clin Pharmacol Ther. 2025 Jul 14. Emerg Microbes Infect. 2025 Dec;14(1):2470371. Endocrinology. 2022 Jul 1;163(7):bqac076. Environ Sci Technol Lett. 2025 Apr 8. Eur J Pharmacol. 2023 Oct 5:956:175938. Eur J Pharmacol. 2024 Feb 5:964:176261. Eur J Pharmacol. 2025 Feb 5:177357. Exp Cell Res. 2023 Dec 15;433(2):113829. Exp Neurol. 2025 May 16:115305. FEBS Open Bio. 2025 Aug 8. Front Cell Dev Biol. 2022 Mar 3;10:806081. Front Pharmacol. 2025 Apr 30:16:1573032. Inflammation. 2024 Oct 31. Int Immunopharmacol. 2025 Dec 3:166:115644. Int J Mol Sci. 2023 Apr 19;24(8):7492. J Appl Toxicol. 2024 Apr 19 J Appl Toxicol. 2024 Aug;44(8):1198-1213. J Mol Neurosci. 2022 Mar;72(3):565-573. J Nat Prod. 2022 Jul 22;85(7):1738-1750. J Neuroimmunol. 2020 Oct 24:350:577429. J Tradit Complement Med. 2024 Mar 29. Life Sci. 2025 Jun 1:370:123571. Med Gas Res. 2025 Mar 1;15(1):148-155. MedComm (2020). 2024 Aug 31;5(9):e681. Mol Cell. 2021 Jul 1;81(13):2736-2751.e8. Nat Aging. 2025 Aug 26. Naunyn Schmiedebergs Arch Pharmacol. 2023 Dec;396(12):3659-3670. Oncogene. 2022 Dec;41(49):5266-5278. Oncologie. 2025 May 26. Orebro University. 2024. Phytomedicine. 2023 Jul 26;119:154997. Phytomedicine. 2025 Jul:142:156713. Phytomedicine. 2025 Oct:146:157128. Proteomics. 2023 Aug;23(16):e2300041. Research Square Preprint. 2021 Dec. Research Square Preprint. 2022 Jun. Research Square Preprint. 2024 Apr 9. Sci Rep. 2020 Jan 28;10(1):1308. Signal Transduct Target Ther. 2023 Dec 25;8(1):457. Signal Transduct Target Ther. 2025 Nov 12;10(1):366. SSRN. 2025 Apr 9.
Smiles	FC1=CC=C(C2=C(C3=CC=CC=C3)C(C(NC4=CC=CC=C4)=O)=C(C(C)C)N2CC[C@@H](O)C[C@@H](O)CC([O-])=O)C=C1.[0.5Ca2+]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CI-981,Atorvastatin hemicalcium
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Category	Reference compound / Active compounds; API
Manufacturer - Targets	Autophagy; Ferroptosis; HMG-CoA Reductase (HMGCR)
Manufacturer - HS Code	H302, H315, H319, H335
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	577.67
Product Description	Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3].
Manufacturer - Research Area	Metabolic Disease; Inflammation/Immunology; Cancer
Solubility	DMSO : ≥ 50 mg/mL\|H2O : < 0.1 mg/mL
Manufacturer - Pathway	Apoptosis; Autophagy; Metabolic Enzyme/Protease
Clinical information	Launched
UNSPSC Code	12352005
Precautionary	H302, H315, H319, H335

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