Talipexole

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 100mg
ArtNr HY-A0040-100mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
B-HT 920, B-HT920
CAS No.
101626-70-4
Purity
>98%
MW
2093112
Formula
C10H15N3S
Solubility
10 mM in DMSO
Biological Description
Talipexole (B-HT920) is a dopamine agonist that has been proposed as an antiparkinsonian agent.
Target: Dopamine Receptor
B-HT920 is a selective alpha 2-adrenoceptor agonist. The effects of B-HT920 have been specified using the alpha-adrenergic antagonists yohimbine and prazosin and the dopamine antagonist haloperidol. Yohimbine could not antagonize any of the actions of B-HT920. Pretreatment with prazosin showed a decrease in the loss of body weight caused by B-HT920, while pretreatment with yohimbine showed that B-HT920 induced an increased loss in body weight. These data suggest that B-HT920 under certain conditions exerts dopamine-agonistic actions in stimulating locomotor activity and alpha 1-adrenergic actions in inducing salivation and enhanced loss of body weight [1]. Concomitant treatment with talipexole, an anti-parkinsonian drug, inhibited MPTP-induced autolysis and individual death in a concentration-dependent manner. Pramipexole showed a similar protective effect. In addition, post-treatment with talipexole at 1 hr after MPTP completely inhibited MPTP-induced individual death. Although MPTP treatment caused 30% of the planarians to undergo autolysis and individual death within 12 hr, post-treatment with talipexole even at 12 hr completely rescued the remaining 70% of the planarians from death. These results suggest that the MPTP-treated planarian may be useful as a novel parkinsonian model in which talipexole has a protective effect even in the case of post-treatment [2].
Menge: 100mg
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