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Talipexole Europäischer Partner

ArtNr HY-A0040-5mg
Hersteller MedChem Express
CAS-Nr. 101626-70-4
Menge 5mg
Quantity options 100mg 10mg 25mg 50mg 5mg
Kategorie
Typ Inhibitors
Specific against other
Formula C10H15N3S
Citations [1]Van der Laan, J.W., Dopaminergic and alpha 1-adrenergic properties of B-HT920 revealed in morphine-dependent rats. Pharmacol Biochem Behav, 1987. 26(2): p. 265-9.<br/>[2]Kitamura, Y., J. Kakimura, and T. Taniguchi, Protective effect of talipexole on MPTP-treated planarian, a unique parkinsonian worm model. Jpn J Pharmacol, 1998. 78(1): p. 23-9.
Smiles NC(S1)=NC2=C1CCN(CC=C)CC2
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias B-HT 920
Lieferbar
Product Description
Talipexole (B-HT920) is a dopamine agonist that has been proposed as an antiparkinsonian agent. Target: Dopamine Receptor B-HT920 is a selective alpha 2-adrenoceptor agonist. The effects of B-HT920 have been specified using the alpha-adrenergic antagonists yohimbine and prazosin and the dopamine antagonist haloperidol. Yohimbine could not antagonize any of the actions of B-HT920. Pretreatment with prazosin showed a decrease in the loss of body weight caused by B-HT920, while pretreatment with yohimbine showed that B-HT920 induced an increased loss in body weight. These data suggest that B-HT920 under certain conditions exerts dopamine-agonistic actions in stimulating locomotor activity and alpha 1-adrenergic actions in inducing salivation and enhanced loss of body weight [1]. Concomitant treatment with talipexole, an anti-parkinsonian drug, inhibited MPTP-induced autolysis and individual death in a concentration-dependent manner. Pramipexole showed a similar protective effect. In addition, post-treatment with talipexole at 1 hr after MPTP completely inhibited MPTP-induced individual death. Although MPTP treatment caused 30% of the planarians to undergo autolysis and individual death within 12 hr, post-treatment with talipexole even at 12 hr completely rescued the remaining 70% of the planarians from death. These results suggest that the MPTP-treated planarian may be useful as a novel parkinsonian model in which talipexole has a protective effect even in the case of post-treatment [2].
Shipping
Room temperature
Manufacturers Applications
Neuroscience-Neurodegeneration
MolecularWeight
209.31
Clinical Information
Launched
Manufacturers Research Area
Neurological Disease
Solubility
10 mM in DMSO
Target
Dopamine Receptor
Manufacturers Target
Dopamine Receptor
Manufacturers Pathway
GPCR/G Protein; Neuronal Signaling
Manufacturers Product type
Reference compound

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Menge: 5mg
Lieferbar: In stock
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