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L-Ascorbic acid (sodium salt)

L-Ascorbic acid (sodium salt)

ArtNr	HY-B0166A-10mM
Hersteller	MedChem Express
CAS-Nr.	134-03-2
Menge	10 mM/1 mL
Quantity options	10 g 10 mM/1 mL 1 g 500 mg 5 g
Kategorie	Food Safety Inhibitors & Compound Libraries Small Molecules Food Additives Antioxidants
Typ	Inhibitors
Specific against	other
Purity	99.97
Citations	[1]Hinek A, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.\|[2]Yang X, et al. Mouse melanoma cell line B16F10-derived conditioned medium inhibits sodium L-ascorbate-induced B16F10 cell apoptosis. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Feb;32(2):146-50.\|[3]Morimura K, et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7.\|[4]Takagi H, et al. Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model. Cancer Lett. 2005 Mar 10;219(2):147-53.\|[5]Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.\|[6]Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83. Environ Toxicol. 2021 Apr;36(4):520-529. FASEB J. 2020 Sep;34(9):11474-11487. Hematol Oncol. 2024 Jul;42(4):e3295. J Afr Ass Physiol Sci. 7(1): 30-37, July 2019. Med Rev (2021). 2024 Jun 14;4(6):531-543. Mil Med Res. 2020 Nov 1;7(1):52. Nat Commun. 2025 Jul 18;16(1):6621. ACS Nano. 2025 Mar 18;19(10):10180-10198. Adv Mater. 2024 Dec 26:e2415543. Anim Biotechnol. 2024 Nov;35(1):2404043. Antioxid Redox Signal. 2020 Dec 10;33(17):1191-1208. Antioxidants (Basel). 2024 May 27;13(6):653. Biochem Biophys Res Commun. 2024 May 14:708:149770. Biol Methods Protoc. 2025 Feb 13;10(1):bpaf012. Biol Pharm Bull. 2025;48(6):895-907. Biomaterials. 2024 Aug 15:313:122756. Biomed Pharmacother. 2022 Sep:153:113558. Bioorg Chem. 2021 Oct:115:105177. Bioorg Chem. 2024 May:146:107261. Bioorg Chem. 2025 Jan 5:155:108133. bioRxiv. 2025 August 25. Biosci Rep. 2019 May 21;39(5):BSR20182137. Bone Res. 2025 Mar 3;13(1):30. Cancer Cell Int. 2024 May 31;24(1):192. Cancer Cell. 2024 Apr 8;42(4):682-700.e12. Cell Biol Toxicol. 2023 Jun;39(3):679-702. Cell Cycle. 2023 Feb;22(4):476-493. Cell Host Microbe. 2024 Dec 12:S1931-3128(24)00444-X. Clin Exp Pharmacol Physiol. 2024 Nov;51(11):e13923. Cytotechnology. 2021 Dec;73(6):787-800. Drug Chem Toxicol. 2024 May;47(3):347-355. Eur J Med Chem. 2022 Mar 5:231:114151. Fitoterapia. 2021 Sep:153:104984. Food Biosci. 2025 Sep 18;73:107628. Food Funct. 2022 May 10;13(9):5089-5101. Free Radic Biol Med. 2020 Feb 1;147:220-230. Front Cell Dev Biol. 2022 Feb 10:10:810327. Genes (Basel). 2024 Sep 13;15(9):1206. Ind Crops Prod. 2025 Oct 18;237:122143. Int J Biol Macromol. 2024 Jan;256(Pt 1):127779. Int J Biol Macromol. 2025 May 15:144179. Int J Mol Sci. 2025 Feb 5;26(3):1334. iScience. 2024 Feb 5;27(3):109111. IUBMB Life. 2024 Oct;76(10):832-844. J Adv Res. 2025 May 10:S2090-1232(25)00309-1. J Agric Food Chem. 2025 Jun 4;73(22):13891-13901. J Biol Chem. 2023 Dec;299(12):105462. J Cell Mol Med. 2020 Apr;24(7):4212-4222. J Cell Physiol. 2024 May;239(5):e31215. J Ethnopharmacol. 2024 Nov 29:340:119128. J Mol Histol. 2024 Aug;55(4):503-512. J Nat Prod. 2022 Jul 22;85(7):1808-1815. J Neuroinflammation. 2025 Sep 24;22(1):211. J Neurosci Res. 2019 Dec;97(12):1689-1705. J Orthop Surg Res. 2025 Apr 15;20(1):379. J Orthop Surg Res. 2025 Nov 14;20(1):997. J Orthop Surg Res. 2025 Oct 29;20(1):943. J Pharmacol Toxicol Methods. Nov-Dec 2020;106:106913. J Sex Med. 2018 Feb;15(2):136-147. Mater Today Bio. 2025 Jun 21:33:102009. Mol Biol Rep. 2024 Mar 14;51(1):421. Mol Med Rep. 2019 Dec; 20(6): 4933–4942. Mol Pharmacol. 2025 Sep 28. Nat Immunol. 2023 Feb;24(2):280-294. Nigerian Journal of Scientific Research. 18 (3): 2019. Oxid Med Cell Longev. 2022 Jan 27:2022:7502632. Redox Biol. 2022 Aug;54:102392. Redox Rep. 2024 Dec;29(1):2428147. Res Sq. 2025 Jul 21. Res Sq. 2025 Oct 27. Research Square Print. 2022 Aug. Sci China Life Sci. 2018 Oct;61(10):1151-1167. SSRN. 2025 Jan 14.
Smiles	O[C@@H](CO)[C@]1([H])C(O[Na])=C(O)C(O1)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Sodium ascorbate,Sodium L-ascorbate,Vitamin C (sodium salt)
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Category	Reference compound / Active compounds; API; Natural Products
Manufacturer - Targets	Apoptosis; Calcium Channel; Endogenous Metabolite; Reactive Oxygen Species (ROS)
Manufacturer - HS Code	H302, H315, H319, H335
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	198.11
Product Description	L-Ascorbic acid sodium salt (Sodium ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3].
Manufacturer - Research Area	Cancer
Solubility	DMSO : 1 mg/mL (ultrasonic)\|H2O : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Clinical information	Launched
Isoform	Microbial Metabolite; T-type calcium channel
UNSPSC Code	12352005
Precautionary	H302, H315, H319, H335

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