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Prazosin (hydrochloride)

Prazosin (hydrochloride)

ArtNr	HY-B0193A-500mg
Hersteller	MedChem Express
CAS-Nr.	19237-84-4
Menge	500 mg
Quantity options	100 mg 10 mM/1 mL 200 mg 500 mg
Kategorie	Oncology Metabolism Diabetes Glucose Homeostasis Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer
Typ	Inhibitors
Specific against	other
Purity	99.93
Citations	[1]Dennis D Rasmussen, et al. The alpha1-adrenergic receptor antagonist, prazosin, reduces alcohol drinking in alcohol-preferring (P) rats. Alcohol Clin Exp Res. 2009 Feb;33(2):264-72.\|[2]W S Colucci, et al. Nonlinear relationship between alpha 1-adrenergic receptor occupancy and norepinephrine-stimulated calcium flux in cultured vascular smooth muscle cells.Mol Pharmacol. 1985 May;27(5):517-24.\|[3]Deborah L White, et al. OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib.Blood. 2006 Jul 15;108(2):697-704.\|[4]Jing Zhang, et al. Prazosin inhibits the proliferation, migration and invasion, but promotes the apoptosis of U251 and U87 cells via the PI3K/AKT/mTOR signaling pathway. Exp Ther Med. 2020 Aug;20(2):1145-1152. bioRxiv. 2024 November 03.\|BMC Pulm Med. 2021 Jun 5;21(1):189.\|Cell Discov. 2023 Feb 7;9(1):16.\|Cell Rep Med. 2024 Oct 1:101771.\|iScience. 2025 Jan 17;28(2):111831.\|J Exp Med. 2023 Nov 6;220(11):e20230577.\|J Transl Med. 2022 Oct 2;20(1):444.\|Am J Pathol. 2023 Apr 21;S0002-9440(23)00132-3.\|Biomed Pharmacother. 2020 Apr;124:109731.\|Cells. 2023 May 24, 12(11), 1461.\|Drug Des Devel Ther. 2024 Apr 9:18:1103-1114.\|Elife. 2024 May 29.\|J Med Chem. 2021 Mar 11;64(5):2725-2738.
Smiles	O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)C4=CC=CO4.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	19237-84-4
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Adrenergic Receptor; Autophagy
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	419.86
Product Description	Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders[1]. Prazosin hydrochloride potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM[2].Prazosin hydrochloride inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8, and 13 μM, respectively[3].
Manufacturer - Research Area	Cardiovascular Disease; Endocrinology; Cancer
Solubility	DMSO: 14.29 mg/mL (ultrasonic)\|H2O: 0.59 mg/mL (ultrasonic)
Manufacturer - Pathway	Autophagy; GPCR/G Protein; Neuronal Signaling
Isoform	α adrenergic receptor
Clinical information	Launched

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HY-B0193A-500mg-safety-datasheet.pdf