« Back
Home /
Prazosin (hydrochloride)

Prazosin (hydrochloride)

Item no.	HY-B0193A-500mg
Manufacturer	MedChem Express
CASRN	19237-84-4
Amount	500 mg
Quantity options	100 mg 10 mM/1 mL 200 mg 500 mg
Category	Oncology Metabolism Diabetes Glucose Homeostasis Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer
Type	Inhibitors
Specific against	other
Purity	99.93
Citations	[1]Dennis D Rasmussen, et al. The alpha1-adrenergic receptor antagonist, prazosin, reduces alcohol drinking in alcohol-preferring (P) rats. Alcohol Clin Exp Res. 2009 Feb;33(2):264-72.\|[2]W S Colucci, et al. Nonlinear relationship between alpha 1-adrenergic receptor occupancy and norepinephrine-stimulated calcium flux in cultured vascular smooth muscle cells.Mol Pharmacol. 1985 May;27(5):517-24.\|[3]Deborah L White, et al. OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib.Blood. 2006 Jul 15;108(2):697-704.\|[4]Jing Zhang, et al. Prazosin inhibits the proliferation, migration and invasion, but promotes the apoptosis of U251 and U87 cells via the PI3K/AKT/mTOR signaling pathway. Exp Ther Med. 2020 Aug;20(2):1145-1152. bioRxiv. 2024 November 03.\|BMC Pulm Med. 2021 Jun 5;21(1):189.\|Cell Discov. 2023 Feb 7;9(1):16.\|Cell Rep Med. 2024 Oct 1:101771.\|iScience. 2025 Jan 17;28(2):111831.\|J Exp Med. 2023 Nov 6;220(11):e20230577.\|J Transl Med. 2022 Oct 2;20(1):444.\|Am J Pathol. 2023 Apr 21;S0002-9440(23)00132-3.\|Biomed Pharmacother. 2020 Apr;124:109731.\|Cells. 2023 May 24, 12(11), 1461.\|Drug Des Devel Ther. 2024 Apr 9:18:1103-1114.\|Elife. 2024 May 29.\|J Med Chem. 2021 Mar 11;64(5):2725-2738.
Smiles	O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)C4=CC=CO4.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	19237-84-4
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Adrenergic Receptor; Autophagy
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	419.86
Product Description	Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders[1]. Prazosin hydrochloride potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM[2].Prazosin hydrochloride inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8, and 13 μM, respectively[3].
Manufacturer - Research Area	Cardiovascular Disease; Endocrinology; Cancer
Solubility	DMSO: 14.29 mg/mL (ultrasonic)\|H2O: 0.59 mg/mL (ultrasonic)
Manufacturer - Pathway	Autophagy; GPCR/G Protein; Neuronal Signaling
Isoform	α adrenergic receptor
Clinical information	Launched

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

HY-B0193A-500mg-safety-datasheet.pdf