Thiabendazole

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Clon N/A
Menge 5g
ArtNr HY-B0263-5g
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
2-(4-Thiazolyl)benzimidazole
CAS No.
148-79-8
Purity
>98%
MW
2012477
Formula
C10H7N3S
Solubility
10 mM in DMSO
Biological Description
Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property.
Target: Fumarate Reductase
Tiabendazole serves to block angiogenesis in both frog embryos and human cells. It has also been shown to serve as a vascular disrupting agent to reduce newly established blood vessels. Tiabendazole has been shown to effectively do this in certain cancer cells. Thiabendazole works by inhibition of the mitochondrial, helminth-specific enzyme, fumarate reductase, with possible interaction with endogenous quinone [1].
Thiabendazole inhibited B16F10 proliferation in vitro in a dose- and time-dependent manner with an IC50 of 532.4 +/- 32.6, 322.9 +/- 28.9, 238.5 +/- 19.8 microM at 24, 48, and 72 h, respectively. Moreover, thiabendazole inhibited the angiogenesis and the migration of B16F10 cells in vitro. Furthermore, thiabendazole restrained transcription and translation of the VEGF gene in B16F10 in vitro, and the apoptotic percentage of B16F10 cells was increased after exposure to thiabendazole [2].
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Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 5g
Lieferbar: In stock
Listenpreis: 190,36 €
Rabatt: -10,0%
Preis: 171,32 €
Sie sparen: 19,04 €
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