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Amiloride hydrochloride dihydrate

Amiloride hydrochloride dihydrate

ArtNr	HY-B0285B-10mM
Hersteller	MedChem Express
CAS-Nr.	17440-83-4
Menge	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL
Kategorie	Food Safety Proteins Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.85
Formula	C6H13Cl2N7O3
Citations	Transl Res. 2023 Sep 5;S1931-5244(23)00143-3. ACS Nano. 2023 Apr 14. Adv Funct Mater. 2024 Oct 31. Adv Sci (Weinh). 2023 Dec 14:e2307880. Am J Transl Res. 2021 Jul 15;13(7):7538-7555. Cell Commun Signal. 2023 May 4;21(1):99. Cell Metab. 2022 Dec 6;34(12):2018-2035.e8. Cell Physiol Biochem. 2018;51(6):2564-2574. Commun Biol. 2022 Nov 14;5(1):1248. Environ Sci Technol. 2021 Feb 11. Int J Biol Macromol. 2024 Aug 5;277(Pt 3):134517. J Am Chem Soc. 2018 Dec 12;140(49):17234-17240. J Control Release. 2024 Oct 26:S0168-3659(24)00725-9. J Leukoc Biol. 2024 Jul 16:qiae159. J Nanobiotechnology. 2020 Jan 31;18(1):26. J Pharmaceut Biomed. 2020, 113870. Microb Pathog. 2019 Jul 18:103638. Nanotechnology. 2018 Feb 23;29(8):085101. Nat Biomed Eng. 2024 Sep 13. Nat Nanotechnol. 2024 Aug 26. Small Methods. 2020 Dec 18. Theranostics. 2019 May 31;9(13):3732-3753. Acta Pharm Sin B. 2024 Jul 27. Biomaterials. 2022 May;284:121529. Br J Pharmacol. 2020 Aug;177(15):3473-3488. Cell Mol Immunol. 2024 Jun 13. Cell Rep. 2022 May 31;39(9):110880. Food Chem. 2024 Sep 8;463(Pt 1):141196. Int J Biol Macromol. 14 March 2022. iScience. 19 October 2022, 105403. J Ethnopharmacol. 2022 Mar 5;115171. J Neuroinflammation. 2022 Feb 22;19(1):53. Sci Total Environ. 2021, 146523. Theranostics. 2020 May 17;10(15):6581-6598. [1]Miller RL, et al. Blockade of ENaCs by amiloride induces c-Fos activation of the area postrema. Brain Res. 2015 Mar 19;1601:40-51. [2]Xu LB, et al. Amiloride, a urokinase-type plasminogen activator receptor (uTPA) inhibitor, reduces proteinurea in podocytes. Genet Mol Res. 2015 Aug 14;14(3):9518-29. [3]Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 7;29(7):1176-91.
Smiles	O=C(C1=NC(Cl)=C(N)N=C1N)NC(N)=N.[H]Cl.O.O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	MK-870 hydrochloride dihydrate
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Targets	Apoptosis; Sodium Channel; TRP Channel
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	302.12
Product Description	Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2[3]) channel.
Manufacturer - Research Area	Metabolic Disease; Cardiovascular Disease
Solubility	DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : 2 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Clinical information	Launched

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HY-B0285B-10mM-safety-datasheet.pdf