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Amiloride hydrochloride dihydrate

Amiloride hydrochloride dihydrate

ArtNr	HY-B0285B-100mg
Hersteller	MedChem Express
CAS-Nr.	17440-83-4
Menge	100 mg
Quantity options	100 mg 10 mM/1 mL
Kategorie	Food Safety Proteins Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.88
Citations	[1]Miller RL, et al. Blockade of ENaCs by amiloride induces c-Fos activation of the area postrema. Brain Res. 2015 Mar 19;1601:40-51.\|[2]Xu LB, et al. Amiloride, a urokinase-type plasminogen activator receptor (uTPA) inhibitor, reduces proteinurea in podocytes. Genet Mol Res. 2015 Aug 14;14(3):9518-29.\|[3]Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 7;29(7):1176-91. Transl Res. 2024 Jan:263:53-72. ACS Nano. 2023 May 9;17(9):8141-8152. Acta Biomater. 2025 Jul 1:201:171-186. Adv Funct Mater. 2024 Oct 31. Adv Funct Mater. 2025 Aug 3. Adv Sci (Weinh). 2024 Mar;11(9):e2307880. Adv Sci (Weinh). 2025 May 14:e2406150. Am J Transl Res. 2021 Jul 15;13(7):7538-7555. Anal Chem. 2025 Jun 17;97(23):12026-12034. Biomaterials. 2026 Jan:324:123541. Cell Commun Signal. 2023 May 4;21(1):99. Cell Metab. 2022 Dec 6;34(12):2018-2035.e8. Cell Mol Biol Lett. 2024 Dec 3;29(1):149. Cell Physiol Biochem. 2018;51(6):2564-2574. Cell Rep Med. 2025 Jul 15;6(7):102208. Commun Biol. 2022 Nov 14;5(1):1248. Environ Sci Technol. 2021 Mar 2;55(5):3144-3155. FASEB J. 2025 Jan 15;39(1):e70298. Int J Biol Macromol. 2024 Aug 5;277(Pt 3):134517. J Am Chem Soc. 2018 Dec 12;140(49):17234-17240. J Control Release. 2024 Oct 26:S0168-3659(24)00725-9. J Control Release. 2025 Nov 20:389:114450. J Hazard Mater. 2025 Dec 5:500:140498. J Leukoc Biol. 2024 Jul 16:qiae159. J Nanobiotechnology. 2020 Jan 31;18(1):26. J Pharm Anal. 2025 Jul;15(7):101182. J Pharm Biomed Anal. 2021 Feb 20:195:113870. Mater Today Bio. 2025 Mar 27:32:101712. Microb Pathog. 2019 Jul 18:103638. Mol Neurodegener. 2025 Jul 23;20(1):84. Mol Pharm. 2025 Apr 7;22(4):2182-2192. Nanotechnology. 2018 Feb 23;29(8):085101. Nat Biomed Eng. 2024 Nov;8(11):1469-1482. Nat Nanotechnol. 2024 Dec;19(12):1903-1913. Small Methods. 2021 Apr;5(4):e2001047. Theranostics. 2019 May 31;9(13):3732-3753. University of Toronto. 2025. Acta Pharm Sin B. 2024 Dec;14(12):5418-5434. Adv Sci (Weinh). 2025 Apr 3:e2412356. Biomaterials. 2022 May;284:121529. Biosens Bioelectron. 2025 Jan 25:274:117184. Br J Pharmacol. 2020 Aug;177(15):3473-3488. Cell Mol Immunol. 2024 Aug;21(8):826-841. Cell Rep. 2022 May 31;39(9):110880. Food Chem. 2024 Sep 8;463(Pt 1):141196. Int J Biol Macromol. 2022 May 15:207:559-569. iScience. 2022 Oct 19;25(12):105403. J Cell Biol. 2025 May 5;224(5):e202405060. J Ethnopharmacol. 2022 Jun 28:292:115171. J Neuroinflammation. 2022 Feb 22;19(1):53. J Zhejiang Univ Sci B. 2025 May 28;26(5):461-476. mBio. 2025 Mar 12;16(3):e0378724. Res Sq. 2025 Nov 16. Sci Total Environ. 2021 Jul 20:779:146523. SSRN. 2025 Aug 21. Theranostics. 2020 May 17;10(15):6581-6598.
Smiles	O=C(C1=NC(Cl)=C(N)N=C1N)NC(N)=N.[H]Cl.O.O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	MK-870 hydrochloride dihydrate
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Category	Reference compound / Active compounds; API
Manufacturer - Targets	Apoptosis; Sodium Channel; TRP Channel
Manufacturer - HS Code	H302, H312, H315, H319, H332, H335
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	302.12
Product Description	Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2[3]) channel.
Manufacturer - Research Area	Metabolic Disease; Cardiovascular Disease
Solubility	DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : 2 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Clinical information	Launched
UNSPSC Code	12352005
Precautionary	H302, H312, H315, H319, H332, H335

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