Ciprofloxacin

ArtNr	HY-B0356-1g
Hersteller	MedChem Express
CAS-Nr.	85721-33-1
Menge	1 g
Quantity options	1 g 500 mg 5 g
Kategorie	Food Safety Antibiotics Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.96
Citations	[1]Tsai WC, et, al. Ciprofloxacin-mediated cell proliferation inhibition and G2/M cell cycle arrest in rat tendon cells. Arthritis Rheum. 2008 Jun;58(6):1657-63.\|[2]Steenbergen J, et, al. In Vitro and In Vivo Activity of Omadacycline against Two Biothreat Pathogens, Bacillus anthracis and Yersinia pestis. Antimicrob Agents Chemother. 2017 Apr 24;61(5):e02434-16.\|[3]Hamblin KA, et, al. Inhaled Liposomal Ciprofloxacin Protects against a Lethal Infection in a Murine Model of Pneumonic Plague. Front Microbiol. 2017 Feb 6;8:91.\|[4]LeMaire SA, et, al. Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice. JAMA Surg. 2018 Sep 1;153(9):e181804. Adv Sci (Weinh). 2020 Jul 21;7(17):2001374. Anal Chim Acta. 2022 Aug 15:1221:340082. Anim Dis. 2021;1(1):26. Antimicrob Agents Chemother. 2025 May 23:e0024925. Appl Biochem Biotechnol. 2025 Aug 23. Appl Microbiol Biotechnol. 2022 Apr;106(7):2689-2702. Arab J Chem. 2024 May, 17, 5, 105745. bioRxiv. 2024 May 10. bioRxiv. 2024 Nov 06. Cardiovasc Toxicol. 2024 Sep;24(9):889-903. Chemosphere. 2019 Jun:225:378-387. Diagn Microbiol Infect Dis. 2025 Nov 4;114(2):117181. EBioMedicine. 2022 Apr;78:103943. Eur J Clin Microbiol Infect Dis. 2025 Sep 29. Front Microbiol. 2022 Feb 16:12:773664. Genome Biol. 2023 Apr 30;24(1):98. Infect Drug Resist. 2025 Oct 4:18:5239-5247. Int J Antimicrob Agents. 2018 Aug;52(2):269-271. iScience. 2023 Oct 7;26(11):108158. J Antimicrob Chemother. 2020 Jul 1;75(7):1850-1858. J Med Chem. 2025 Dec 11;68(23):25274-25289. Microb Pathog. 2024 Jun:191:106666. Microbiol Spectr. 2022 Apr 25:e0251821. Microbiol Spectr. 2022 Feb 23;10(1):e0099121. Microbiol Spectr. 2025 May 19:e0307424. Molecules. 2023 Jun 8;28(12):4628. Nat Cell Biol. 2024 Sep;26(9):1545-1557. Nature. 2024 Aug;632(8027):1137-1144. NPJ Biofilms Microbiomes. 2024 Oct 28;10(1):111. Orebro University. 2024. Patent. US20200101105A1. PLoS Pathog. 2024 Dec 31;20(12):e1012783. Research Square Preprint. 2020 Jun. Vet Microbiol. 2024 May:292:110046. Virulence. 2024 Dec;15(1):2415952. Water Res. 2023 Jul 15:240:120110. Water Res. 2024 Nov 29:271:122885. Water. 2025 Jun 6. ACS Appl Polym Mater. 2023 Aug 29. bioRxiv. 2024 Jan 18. Chem Eng J. 2025 May 1. Anim Dis. 2021;1(1):26. Arch Pharm Res. 2025 Jan;48(1):102-114. bioRxiv. 2024 Feb 9. Nat Commun. 2022 Mar 2;13(1):1116.
Smiles	O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CCNCC4)=C3)C1=O)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Bay-09867
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Category	Lead-like compounds; Reference compound / Active compounds; API
Manufacturer - Targets	Antibiotic; Apoptosis; Bacterial; Mitochondrial Metabolism; Reactive Oxygen Species (ROS); Topoisomerase
Manufacturer - HS Code	H315, H319, H335
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	331.34
Product Description	Ciprofloxacin (Bay-09867) is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin has anti-proliferative activity and induces apoptosis. Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity[1][2][3][4].
Manufacturer - Research Area	Cancer; Infection
Solubility	0.1 M HCl : 16.67 mg/mL (ultrasonic; warming; adjust pH to 2 with HCl; heat to 60°C)\|DMSO : 4.86 mg/mL (ultrasonic; warming; adjust pH to 5 with 1 M HCl; heat to 60°C)\|H2O : 6.78 mg/mL (ultrasonic; warming; adjust pH to 3 with 1 M HCl; heat to 60°C)
Manufacturer - Pathway	Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Clinical information	Launched
Isoform	Quinolone
UNSPSC Code	12352005
Precautionary	H315, H319, H335

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