Lerisetron

Non Antibodies

5-HT3A receptors

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

292, 4

A Potent Antagonist of 5-HT3 Channels

100-150 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

41116134

Lerisetron inhibits the 5-HT-induced Bezold-Jarisch reflex in anesthetized rats, pKi = 9.21.

Yes

Lerisetron, a piperazinylbenzimidazole derivative, is a potent and highly selective blocker of serotonin 5-HT3 channels with antiemetic effects. The drug is shown to be effective in the treatment of nausea and vomiting caused by emetogenic cytotoxic drugs1, 2.Lerisetron antagonizes the serotonin action on the presynaptic 5-HT3 receptor that is implicated at the emetic reflex2, 3.The 5-HT3 receptor mediates the action of serotonin in the body. This receptor is a member of the Cys-loop ligand-gated cation channels, which are expressed throughout the central and peripheral nervous systems and mediates a variety of physiological functions such as: emotion, cognition, memory, pain perception, and gastrointestinal functions including secretion and motility4.