Enarodustat

1262132-81-9

340.33

DMSO : 83.33 mg/mL (244.85 mM; Need ultrasonic)

Metabolic Enzyme/Protease

Enarodustat is a potent and orally active factor prolyl hydroxylase inhibitor, with an EC₅₀ of 0.22 uM. Enarodustat has the potential for renal anemia treatment. IC50 & Target: EC50: 0.22 uM (factor prolyl hydroxylase)^[1] In Vitro: Enarodustat (JTZ-951) is a potent and orally active factor prolyl hydroxylase inhibitor, with an EC₅₀ of 0.22 uM. Enarodustat exhibits neither CYP (IC₅₀ > 100 uM; CYP3A4/5, CYP2C9, CYP2D6, CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2B6) nor hERG (IC₅₀ > 100 uM) inhibition^[1]. In Vivo: Enarodustat (1 and 3 mg/kg, p.o.) increases hemoglobin levels in a dose-dependent manner with daily oral dosing in rats^[1].