GSK1702934A

924377-85-5

395.52

DMSO : 100 mg/mL (252.83 mM; Need ultrasonic)

Membrane Transporter/Ion Channel; Neuronal Signaling

GSK1702934A is a selective TRPC3 agonist. GSK1702934A modulates cardiac contractility and f arrhythmogenesis by activation of TRPC3^[1][2]. In Vitro: GSK1702934A is able to induce TRPC3/6-currents in HEK293 cells transduced with recombinant human TRPC3/6 with an EC₅₀ of 0.08 mM and 0.44 mM, respectively^[1].
GSK1702934A induces a transient, non-selective conductance and prolonged action potentials in TRPC3-overexpressing myocytes but not in wild-type myocytes^[2].
GSK1702934A substantially promotes NCX currents in TRPC3-overexpressing myocytes^[2].
In Vivo: GSK1702934A (0.3-3 mg/kg; i.v.) transiently increases blood pressure by 15 ca. 35 mmHg in conscious Sprague Dawley rats^[3].