TH5487

2304947-71-3

541.18

DMSO : 25 mg/mL (46.20 mM; Need ultrasonic)

Others

TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC₅₀ of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes^[1]. In Vitro: TH5487 (5 uM; 1 hour) decreases TNFalpha- and LPS-induced proinflammatory gene expression to near pretreatment levels^[1].
TH5487 (0-10 uM; 1 hour) perturbs binding of NF-kappaB to 8-oxoG-containing synthetic DNA in nuclear extracts from MLE 12 or hSAEC cells^[1]. In Vivo: TH5487 (prophylactic intraperitoneally injection; 8-30 mg/kg; 1-9 hours) decreases TNFalpha or LPS induced the robust recruitment of neutrophils to the airways, and reduces the pulmonary neutrophil count in a time-dependent manner^[1].