Hexyl gallate

1087-26-9

254.28

DMSO : 41.67 mg/mL (163.87 mM; Need ultrasonic)

Anti-infection; Anti-infection

Hexyl gallates (Hexyl 3, 4, 5-trihydroxybenzoate) shows antibacterial activity and inhibits the production of rhamnolipid and pyocyanin by inhibiting RhlR^[1]. Hexyl gallate, a alkyl ester derivative of gallic acid, exhibits potent antimalarial activity against Plasmodium falciparum, with IC₅₀ of 0.11 mM^[2]. In Vitro: Hexyl gallates (Hexyl 3, 4, 5-trihydroxybenzoate) inhibits only Rhl-dependent production of rhamnolipid and pyocyanin by inhibiting RhlR, without affecting elastase production and biofilm formation which are regulated by the Las system.Hexyl gallates inhibits pigment production at 10-30?uM, but also exhibited antibacterial activity. Hexyl gallates also exhibits antibacterial activity against CV026 cells. Hexyl gallates inhibits only N-butanoyl homoserine lactone (BHL) production at 100 and 300?uM without affecting N-(3-oxododecanoyl)-l-homoserine lactone (OdDHL) and 2-heptyl-3-hydroxy-4(1?H) quinolone (PQS) production^[1].
Hexyl gallates, an antimicrobial alternative to copper compounds, inhibits Xanthomonas citri growth in a dose-response manner, showing a more pronounced activity at the range of 30-50 ug/ml, and it targets the membrane of X. citri^[3].