Sulfapyridine

144-83-2

249.29

DMSO : 60 mg/mL (240.68 mM; Need ultrasonic); H2O : < 0.1 mg/mL (insoluble)

Anti-infection; Anti-infection

Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC₅₀ of 0.18 uM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities^[1][2][3]. In Vitro: Sulfapyridine inhibits production of IL-8, chemokine (C-X-C motif) ligand 1 (CXCL1), and monocyte chemotactic protein-1 (MCP-1) in synovial cells of rheumatoid arthritis (RA)^[1].
MIC range of Sulfapyridine for Y. enterocolitica is 3.1-25 ug/mL and for Salmonella 25-100 ug/mL. Campylobacter jejuni/coli are less susceptible to Sulfapyridine with MIC values ranging from 200 to 800 ug/mL. Shigella and three of five E. coli strains are resistant to 1600 ug/mL of sulfapyridine. Two strains of E. coli are inhibited by 25 ug/mL^[2]. In Vivo: Sulfapyridine (1 and 10 ug/kg; i.p.) significantly inhibits systemic allergic reaction induced by compound 48/80 in rats^[4].