SC57666

158959-32-1

316.39

DMSO : >= 100 mg/mL (316.07 mM)

Immunology/Inflammation

SC57666 is a selective COX2 inhibitor with an IC₅₀ of 26 nM. IC50 & Target: IC50: 26 nM (COX2)^[1] In Vitro: SC57666 inhibits COX2 with an IC₅₀ of 3.2+/-0.8 nM in CHO cells stably transfected with human COX isozymes, with 1000 fold or more selectivity over COX1 (IC₅₀=6000+/-1900 nM)^[2]. In Vivo: SC57666 has been shown to be orally active (ED₅₀=1.7 mpk) in the adjuvant-induced arthritis model. No gastric lesions are observed in mice after 5 h when SC57666 is administered intragastrically at 600 mpk. No intestinal damage is observed in rats after 72 h when SC57666 is administered intragastrically at 200 mpk^[1].