17-AAG

Blue Ice

585, 7

Supplied as a dark purple solid.

Inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin. Subsequently inhibits the activity of oncogenic proteins such as p185erbB-2 (IC50 = 31nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo. Also protects neuroprogenitor cells against stress-induced apoptosis at low concentrations (10nM) in vitro.

Synonyms:
NSC 330507, 17-(Allylamino)-17-demethoxygeldanamycin, Tanespimycin

CAS Number:
75747-14-7

Molecular Weight:
585.7

Molecular Formula:
C31H43N3O8

Method for Determining Identity:
Mass Spectrometric Analysis

Solubility:
DMSO to 100mM

Appearance:
Supplied as a dark purple solid.

Purity:
≥98%

Storage and Stability:
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.