Pramipexole (SND-919)

Description: Pramipexole (also known as SND 919), an agonist of the Galphai-linked dopamine receptors D2, D3, and D4, is a potent dopamine agonist of the non-ergoline class. It is used for the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS). Pramipexole also possesses low/insignificant affinity (500-10, 000 nM) for the 5-HT1A, 5-HT1B, 5-HT1D, and alpha2-adrenergic receptor. Pramipexole is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.

References: Clin Ther. 2006 Aug; 28(8):1065-78.

Related CAS: 191217-81-9 (Pramipexole 2HCl Monohydrate); 104632-25-9 (HCl)