NU7441 (KU57788)

ArtNr	V0108-25mg
Hersteller	InvivoChem LLC
CAS-Nr.	503468-95-9
Menge	25 mg
Quantity options	100 mg 10 mg 250 mg 50 mg
Kategorie	Reagents & Chemicals Molecules
Typ	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
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Description	InvivoChem Cat #:V0108CAS #:503468-95-9Purity >=98% Description: NU7441 (also called KU-57788) is a highly potent, selective and ATP-competitive inhibitor of DNA-PK (DNA-dependent protein kinase) with IC50 of 14 nM, has anticancer activity. It also inhibits PI3K with IC50 value of 5 uM in cell-free assays. NU7441 showed no inhibition effect on the DNA-PK-related enzymes ATM and ATR at concentration of 100 uM. For mTOR and PI3K, NU7441 exhibited inhibition activities with IC50 values of 1.7 and 5 uM, respectively, which were about 100-fold higher than the IC50 value of DNA-PK. NU7441 sensitized HeLa cells to ionizing radiation in vitro, with dose modification factors of 2.5 at 10% survival being observed at 0.5 microM. Description:Description: NU7441 (also called KU-57788) is a highly potent, selective and ATP-competitive inhibitor of DNA-PK (DNA-dependent protein kinase) with IC50 of 14 nM, has anticancer activity. It also inhibits PI3K with IC50 value of 5 uM in cell-free assays. NU7441 showed no inhibition effect on the DNA-PK-related enzymes ATM and ATR at concentration of 100 uM. For mTOR and PI3K, NU7441 exhibited inhibition activities with IC50 values of 1.7 and 5 uM, respectively, which were about 100-fold higher than the IC50 value of DNA-PK. NU7441 sensitized HeLa cells to ionizing radiation in vitro, with dose modification factors of 2.5 at 10% survival being observed at 0.5 microM. References: J Med Chem. 2005 Dec 1; 48(24):7829-46; Cancer Res. 2006 May 15; 66(10):5354-62. References: References:

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