AZD1480

ArtNr	V0316-250mg
Hersteller	InvivoChem LLC
CAS-Nr.	935666-88-9
Menge	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Kategorie	Reagents & Chemicals Molecules
Typ	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
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Description	InvivoChem Cat #:V0316CAS #:935666-88-9Purity >=98% Description: AZD1480 (AZD-1480) is a selective, orally bioavailable and ATP-competitive inhibitor of JAK2 (Janus-associated kinase) with potential antitumor activity. It inhibits JAK2 with an IC50 of 0.26 nM in a cell-free assay. It shows potent in vitro antiproliferative activity and high in vivo antitumor efficacy, because JAK2 is upregulated/mutated in a variety of cancer cells, mediating STAT3 activation and playing a key role in tumor cell proliferation and survival. Description: Description: AZD1480 (AZD-1480) is a selective, AZD-1480)P-competitive inhibitor of JAK2 with potential antitumor activity. It inhibits JAK2 with an IC50 of 0.26 nM in a cell-free assay. It shows potent in vitro antiproliferative activity and high in vivo antitumor efficacy, because JAK2 is upregulated/mutated in a variety of cancer cells, mediating STAT3 activation and playing a key role in tumor cell proliferation and survival.JAK2 is upregulated/mutated in a variety of cancer cells, mediating STAT3 activation and playing a key role in tumor cell proliferation and survival. References: Blood Cancer J. 2011 Dec; 1(12): e46; Mol Cancer Ther. 2011 Dec; 10(12):2384-93; Cancer Res. 2011 Nov 1; 71(21):6601-10. ReferencesReferences:
	Name: AZD-1480 CAS#: 935666-88-9 Chemical Formula: C14H14ClFN8 Exact Mass: 348.1014 Molecular Weight: 348.76596 Elemental Analysis: C, 48.21; H, 4.05; Cl, 10.17; F, 5.45; N, 32.13
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: AZD-1480; AZD1480; AZD 1480 Chemical Name: (S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2, 4-diamine InChi Key: PDOQBOJDRPLBQU-QMMMGPOBSA-N InChi Code: InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6, 8H, 1-2H3, (H3, 19, 20, 21, 22, 23, 24)/t8-/m0/s1 SMILES Code: CC1=CC(NC2=NC(N[CH](C3=NC=C(F)C=N3)C)=NC=C2Cl)=NN1

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Menge: 250 mg

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