MG-132(R)

Description: MG-132 (R) (R-isomer of MG-132), a peptide aldehyde, is a novel, potent, non-specific, cell permeable and reversible inhibitor 20S proteasome inhibitor, with IC50 of 24.2 nM for the beta5 chymotrypsin-like active site. It can inhibit proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells. In comparison to (S)-MG132, the (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities.

References: J Med Chem. 2010; 53(4):1509-18; J Biol Chem. 2005; 280(31):28394-401; Oncol Rep. 2009; 22(1):215-21.

Related CAS: 133407-82-6 (MG-132)

Publications Citing Use of InvivoChem MG-132: Eur J Med Chem. 2020 May 5; 199:112377

Chemical Name: benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-(((S)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)carbamate

InChi Key: TZYWCYJVHRLUCT-VABKMULXSA-N

InChi Code: InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11, 15, 17-19, 21-23H, 12-14, 16H2, 1-6H3, (H, 27, 31)(H, 28, 32)(H, 29, 33)/t21-, 22-, 23-/m0/s1

SMILES Code: O=C(OCC1=CC=CC=C1)N[CH](CC(C)C)C(N[CH](CC(C)C)C(N[CH](CC(C)C)C=O)=O)=O