ONX-0914 (PR-957)

Description: ONX-0914 (also known as ONX0914; PR957) is a selective inhibitor of LMP7 and LMP2 subunits of immunoproteasomes with the potential to be used in autoimmune diseases including rheumatoid arthritis, inflammatory bowel disease and lupus. It shows minimal cross-reactivity for the constitutive proteasome in a cell-free assay.

References: Nat Med. 2009 Jul; 15(7):781-7.

Synonym: ONX0914; PR-957; ONX 0914; PR 957; ONX-0914; PR957;

Chemical Name: (S)-3-(4-methoxyphenyl)-N-((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)propanamido)propanamide

InChi Key: WQAVPPWWLLVGFK-VTNASVEKSA-N

InChi Code: InChI=1S/C31H40N4O7/c1-21(32-27(36)19-35-13-15-41-16-14-35)29(38)34-26(18-23-9-11-24(40-3)12-10-23)30(39)33-25(28(37)31(2)20-42-31)17-22-7-5-4-6-8-22/h4-12, 21, 25-26H, 13-20H2, 1-3H3, (H, 32, 36)(H, 33, 39)(H, 34, 38)/t21-, 25-, 26-, 31+/m0/s1

SMILES Code: O=C(N[CH](CC1=CC=CC=C1)C([C]2(C)OC2)=O)[CH](NC([CH](NC(CN3CCOCC3)=O)C)=O)CC4=CC=C(OC)C=C4