Desvenlafaxine Succinate (WY 45233; O-Desmethylvenlafaxine)

Description: Desvenlafaxine Succinate (formerly WY45233; WY 45233; O-desmethylvenlafaxine; trade name Pristiq, Desfax), the succinate salt of Desvenlafaxine which is an approved antidepressant drug, is a novel and potent serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively. Desvenlafaxine is the active metabolite of the antidepressant venlafaxine (sold under the trade names Effexor and Efexor). Similar to venlafaxine, Desvenlafaxine inhibits the neuronal uptake of serotonin and norepinephrine. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 uM) at the human dopamine (DA) transporter. Desvenlafaxine is being targeted as the first non-hormonal based treatment for menopause.

References: J Pharmacol Exp Ther. 2006 Aug; 318(2):657-65; Ann Pharmacother. 2008 Oct; 42(10):1439-46.

Related CAS#: 93413-62-8 (free base); 448904-47-0 (succinate); 300827-87-6 (HCl); 93414-04-1 (fumarate); 1147940-37-1 (benzoate); 386750-22-7 (Succinate hydrate)