Fluorouracil (5-Fluoracil, 5-FU)

Description: Fluorouracil (formerly 5-FU; NSC-19893; NSC19893; 5-Fluorouracil), an analogue of uracil, is an approved anticancer medication acting as a potent DNA/RNA synthesis inhibitor. Specifically, it interrupts nucleotide synthesis by inhibiting the enzyme thymidylate synthase (TS) in tumor cells. Fluorouracil is a heterocyclic aromatic organic compound approved for treating various solid tumors such as ovarian cancer, breast cancer, head and neck cancer, and colon cancer.

References: Nat Rev Cancer. 2003 May; 3(5):330-8.

NSC 19893; 5-FU; Fluorouracil; NSC-19893; NSC19893; 5-Fluorouracil; Trade name: Adrucil among many others.

Chemical Name: 5-fluoropyrimidine-2, 4(1H, 3H)-dione

InChi Key: GHASVSINZRGABV-UHFFFAOYSA-N

InChi Code: InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H, (H2, 6, 7, 8, 9)

SMILES Code: O=C1NC(C(F)=CN1)=O