SKF-96365 HCl

Description: SKF-96365 is a novel, potent and selective TRPC channel blocker. SKF-96365 activates cytoprotective autophagy to delay apoptosis in colorectal cancer cells through inhibition of the calcium/CaMKIIgamma/AKT-mediated pathway. SKF-96365 strongly inhibits voltage-gated sodium current in rat ventricular myocytes. SKF 96365 inhibits glioblastoma cell growth by enhancing reverse mode of the Na(+) /Ca(2+) exchanger and increasing intracellular Ca(2+). SKF-96365 attenuates toxin-induced neuronal injury through opposite regulatory effects on Homer1a and Homer1b/c in cultured rat mesencephalic cells.

References: Cheng H, Curtis AE, Fellingham C, Hancox JC. Multiple ion channel block by the cation channel inhibitor SKF-96365 in myocytes from the rabbit atrioventricular node. Physiol Rep. 2016 Jun; 4(11). pii: e12819. doi: 10.14814/phy2.12819. PubMed PMID: 27288059.

Related CAS #: 130495-35-1 (HCl) 162849-90-3 (free base);