bafilomycin-a1-baf-a1

Description: Bafilomycin A1 (formerly known as NSC 381866) is a novel, potent and selective inhibitor of vacuolar H+-ATPase (V-ATPases) with IC50 of 0.44 NM. It is a macrolide antibiotic isolated from the Streptomyces species. The inhibitory effect of bafilomycin A1 on vacuolar ATPases was determined by testing its influence on H+-pumping activity. H+ translocation was completely inhibited by 10 nM bafilomycin A1. Other study has shown that bafilomycin A1 strongly inhibited the pit-forming activity of osteoclasts. The subcellular localization of V-ATPase in osteoclasts was been treated with or without bafilomycin A1 by immunoelectron microscopy. Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice. Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways.

References: Comp Biochem Physiol A Mol Integr Physiol. 2004 Dec; 139(4):425-32; J Bone Miner Res. 1994 Oct; 9(10): 1575-82.

Related CAS #: 88899-56-3 (Bafilomycin B1)

Publications Citing Use of InvivoChem Bafilomycin: Eur J Med Chem. 2020 May 5; 199:112377