tenofovir-disoproxil-fumarate

Description: Tenofovir Disoproxil Fumarate (Tenofovir DF), the Fumarate salt of tenofovir, belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination. It is an antiretroviral medication used to prevent and treat HIV/AIDS and to treat chronic hepatitis B. Shortly upon administration, tenofovir disoproxil fumarate rapidly goes through esterase hydrolysis removing the two ester groups and yielding tenofovir, which is a nucleotide analogue with anti-viral activity against HIV-1/2.

References: Antimicrob Agents Chemother. 2006 Oct; 50(10):3297-304; Antimicrob Agents Chemother. 2002 Mar; 46(3):716-23.

Related CAS#:147127-20-6 (Tenofovir); 206184-49-8 (hydrate); 379270-37-8 (alafenamide); 206184-49-8 (hydrate); 1571075-19-8 (aspartate); 201341-05-1 Tenofovir dsoproxil); 1236287-04-9 (Tenofovir maleate); 1392275-56-7 (Tenofovir alafenamide hemifumarate); 379270-38-9 (Tenofovir alafenamide fumarate); 1464851-21-5 (Z)-9-Propenyladenine; (Z)-Mutagenic Impurity of Tenofovir Disoproxil; 1446486-33-4 9-Propenyladenine; Mutagenic Impurity of Tenofovir Disoproxil; Tenofovir Impurity 2